Overviews of genetics of hereditary breast cancer and therapeutics:
Personalized medicine: PARP inhibitors and BRCA1/BRCA2:
- First in human phase I pharmakinetic (PK) and phramacodynamic (PD) study of KU-0059436 (Ku), a small molecule inhibitor of poly ADP-ribose polymerase (PARP) in cancer patients (p), including BRCA1/2 mutation carriers.
Yap TA, Boss DS, Fong PC, Roelvink M, Tutt A, Carmichael J, O’Connor MJ, Kaye SB, Shellens JH, de Bono JS
http://meeting.ascopubs.org/cgi/content/abstract/25/18_suppl/3529


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